2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Neuropeptide Y Receptor

Neuropeptide Y Receptor

NPY receptor

Neuropeptide Y Receptor

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Neuropeptide Y receptors belong G protein-coupled receptor superfamily and comprise various subtypes. There are currently five cloned NPY receptor subtypes in mammals, termed Y1, Y2, Y4, Y5, and Y6. Neuropeptide Y receptors mediate a variety of physiological responses including feeding and vasoconstriction.

Subtypes Y1, Y2, Y4 and Y5 are expressed in humans. They are present mainly in the central and peripheral nervous systems as well as other tissues, such as the cardiovascular system. Their physiologic ligands are the neurotransmitter Neuropeptide Y and the 2 hormones peptide YY (PYY) and pancreatic polypeptide (PP).

Neuropeptide Y and its receptors regulate important biological and pathophysiological functions, such as blood pressure, neuroendocrine secretions, seizures, neuronal excitability and neuroplasticity.

Neuropeptide Y Receptor Isoform Specific Products:

Neuropeptide Y Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P1250A
    RFRP-3(human) TFA
    		Agonist
    RFRP-3 (Neuropeptide VF(124-131))(human) TFA, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM.
    RFRP-3(human) TFA
  • HY-P3692
    CART (55-76), rat
    CART (55-76), rat is a neuropeptide (55-76 residues of the CART peptide) and constitutes the N-terminal fragments of CART (55-102). CART (55-76), rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (55-76), rat can induce anxiety and stress-related behavior.
    CART (55-76), rat
  • HY-RS09513
    Npy1r Rat Pre-designed siRNA Set A
    		Inhibitor

    Npy1r Rat Pre-designed siRNA Set A contains three designed siRNAs for Npy1r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Npy1r Rat Pre-designed siRNA Set A
  • HY-107724
    PD 160170
    		Antagonist
    PD 160170 is a compound developed to inhibit low-risk myelodysplastic syndrome-associated anemia with activities that promote red blood cell transfusion independence and increase hemoglobin.
    PD 160170
  • HY-P1133
    Galanin (2-29) (rat)
    		Agonist
    Galanin (2-29) (rat) inhibits rat pancreatic protein and CCK-8-stimulated amylase secretion. Galanin (2-29) (rat) is an GAL2R agonist (Ki: 3.5 nM).
    Galanin (2-29) (rat)
  • HY-P5054
    Galanin (1-13)-Neuropeptide Y (25-36) amide
    		Agonist
    Galanin (1-13)-Neuropeptide Y (25-36) amide is a high-affinity ligand for galanin receptors, and galanin itself.
    Galanin (1-13)-Neuropeptide Y (25-36) amide
  • HY-P3676
    Neuropeptide Y (3-36) (porcine)
    		Agonist
    Neuropeptide Y (3-36) (porcine) is an agonist of neuropeptide Y (NPY) receptor subtype Y2, and stimulates feeding in rats. Neuropeptide Y (3-36) (porcine) is a highly Y2 selective ligand compared with nselective Y1/Y2 receptor ligand, Neuropeptide Y 1-36.
    Neuropeptide Y (3-36) (porcine)
  • HY-P1840A
    Galanin Receptor Ligand M35 TFA
    		Antagonist
    Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM). Galanin Receptor Ligand M35 TFA exerts a Ki values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively.
    Galanin Receptor Ligand M35 TFA
  • HY-P5063
    Galanin-Like Peptide (human)
    Galanin-Like Peptide (human) is a 60 amino acid neuropeptide. Galanin-Like Peptide (human) plays an important role in the regulation of feeding, body weight and energy metabolism.
    Galanin-Like Peptide (human)
  • HY-P1321A
    GR231118 TFA
    		Antagonist
    GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pKi= 8.8).
    GR231118 TFA
  • HY-P1128A
    Galanin (swine) (TFA)
    		Agonist
    Galanin (swine) TFA, a neuropeptide, consists of 29 amino acids and contains a C-terminal amidated glycine. Galanin (swine) inhibits basal and stimulated insulin secretion both in vivo and in vitro under a variety of experimental conditions. Galanin (swine) TFA is a galanin receptor agonist with pKis of 9.63, 9.49, 9.02, 8.98, 8.01 and 8.14 at human GAL1, rat GAL1, human GAL2, rat GAL2, human GAL3 and rat GAL3 respectively.
    Galanin (swine) (TFA)
  • HY-118198
    NPY Y2 antagonist 1
    		Antagonist
    NPY Y2 antagonist 1 (compound 36) is a pyridine-type, selective neuropeptide Y receptor (NPY) Y2 antagonist.
    NPY Y2 antagonist 1
  • HY-RS09515
    Npy2r Mouse Pre-designed siRNA Set A
    		Inhibitor

    Npy2r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npy2r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Npy2r Mouse Pre-designed siRNA Set A
  • HY-107727
    BMS-193885 L-Lactic acid
    		Antagonist
    BMS-193885 (L-Lactic acid) is a potent, selective, and brain-penetrant neuropeptide Y1 receptor antagonist. BMS-193885 has a Ki value of 3.3 nM for the neuropeptide Y1 receptor, competitively acts on the neuropeptide Y binding site, and can reduce food intake and body weight through central Y1 inhibition.
    BMS-193885 L-Lactic acid
  • HY-P1322A
    [D-Trp34]-Neuropeptide Y TFA
    		Agonist
    [D-Trp34]-Neuropeptide Y TFA is a potent and selective neuropeptide Y (NPY) Y5 receptor agonist. [D-Trp34]-Neuropeptide Y TFA is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-Trp34]-Neuropeptide Y TFA markedly increases food intake in rats.
    [D-Trp34]-Neuropeptide Y TFA
  • HY-122021
    J-115814
    		Antagonist
    J-115814 is a potent and selective neuropeptide Y1 antagonist with Ki values of 1.4, 1.8, 1.9, >10000, 620, 6000, >10000 nM for hY1, rY1, mY1, hY2, hY4, hY5, mY6, respectively. J-115814 inhibits feeding behaviors.
    J-115814
  • HY-P1400
    Neuropeptide Y (scrambled)
    		Control
    Neuropeptide Y (scrambled) is a scrambled peptide that serves as a negative control for Neuropeptide Y.
    Neuropeptide Y (scrambled)
  • HY-165125
    (S)-VU0637120
    		Antagonist
    (S)-VU0637120 is a Y4R antagonist that effectively reduces the binding response of its endogenous ligand, pancreatic polypeptide (PP), on Y4R, with an IC50 value of 2.7 μM. (S)-VU0637120 binds to the allosteric site of Y4R, which is located in the core region of the Y4R transmembrane structure, near the binding pocket of pancreatic polypeptide (PP), with a KB value of 300-400 nM. (S)-VU0637120 holds potential for research in the field of metabolic diseases.
    (S)-VU0637120
  • HY-U00335
    FR252384
    		Antagonist
    FR252384 is a neuropeptide Y-Y5 receptor antagonist, with an IC50 of 2.3 nM.
    FR252384
Cat. No. Product Name / Synonyms Application Reactivity
Neuropeptide Y Receptor Isoform Comparison

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